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According to a new study, obesity hampers the effect of anti-hypertension and anti-cholesterol drugs. It is a well-known fact that obesity shares a close relationship with hypertension, diabetes and high cholesterol – all the three which trigger cardiovascular diseases.
The lifestyle of obese persons suffering from such medical conditions should be manipulated so that rates of morbidity and mortality can be reduced.
Vineet Bhan of the University of Toronto sought to determine whether “there were differences in reaching guideline-recommended targets for BP and cholesterol levels, according to body mass index (BMI-height to weight ratio) in individuals deemed at high risk for heart disease and stroke”.
"These high risk patients frequently do not reach their blood pressure and cholesterol targets," says Bhan. "The goal of our study was to see if obesity could be a factor."
The study was conducted on 7,357 high risk patients suffering from coronary artery disease, cerebro-vascular disease, diabetes plus additional cardiovascular risk factors from across nine Canadian provinces.
This observational study, based on two outpatient registries, took place from 2001 to 2004, recruiting 95 percent of the patients from family physician offices. The registries were led by senior study co-author Shaun Goodman, and coordinated by the Canadian Heart Research Centre.
"Although a direct cause-and-effect relationship cannot be proven, our data would suggest that pharmacologic (drug) treatment alone without achieving optimal weight may not be adequate," says senior author, Andrew Yan.
"This is a potentially important message to get across to clinicians, especially primary care physicians who are on the front line managing these high risk patients in the long term."
These findings were presented at the 2009 Canadian Cardiovascular Congress.
